What is Osphena?

Osphena (ospemifene) is a prescription oral medication approved by the FDA to treat moderate to severe dyspareunia (painful intercourse) caused by vulvar and vaginal atrophy due to menopause. It is a selective estrogen receptor modulator (SERM) that acts like estrogen in vaginal tissue. (Paraphrased from official labeling)

How Does It Work?

Osphena binds to estrogen receptors in the vaginal walls, promoting tissue thickening and increased lubrication. This helps reduce pain during sexual activity in postmenopausal women. (Based on mechanism from FDA documents)

Who Should Use Osphena?

Osphena is recommended for postmenopausal women experiencing painful sex due to thinning vaginal tissues. It is not suitable for women who are pregnant or have a history of estrogen-dependent cancers.

How is Osphena Taken?

• One 60 mg tablet taken by mouth once daily, with food
• Daily use is required for ongoing symptom relief
• Full benefits may take several weeks

(Dosage based on FDA prescribing label)

Benefits of Osphena

• Improves vaginal tissue thickness and elasticity
• Increases natural lubrication
• Reduces pain during intercourse
• Non-vaginal pill format (oral tablet)

Side Effects and Risks

Common side effects may include:

• Hot flashes
• Vaginal discharge
• Muscle spasms
• Headache
• Increased risk of blood clots

⚠️ Warning: Like estrogen, Osphena may increase the risk of stroke, deep vein thrombosis (DVT), and endometrial cancer. Regular monitoring is advised. (Based on black box warning)

Who Should Avoid Osphena?

• Women with a history of blood clots or stroke
• Those with estrogen-sensitive cancers
• Women with unexplained vaginal bleeding
• Pregnant or breastfeeding women

How Effective Is Osphena?

Clinical trials showed significant improvement in vaginal cell structure and reduction in pain during sex after 12 weeks of consistent use. (Paraphrased from FDA clinical data)

Conclusion

Osphena offers an effective oral alternative to vaginal estrogen treatments for menopausal women suffering from painful intercourse. As with any medication, talk to your healthcare provider to ensure it’s the right fit for your health needs.

Sources / Scientific References:

• FDA Prescribing Information for Osphena
• Official Osphena Website
• Speroff L, Bachmann G, et al. “Ospemifene for Treating Dyspareunia.” Menopause. 2014.
• PubMed Review on Ospemifene