Natesto – Testosterone Nasal Gel
Natesto is a prescription testosterone replacement therapy (TRT) delivered as a nasal gel. It is primarily used to treat adult men diagnosed with hypogonadism, a condition where the body produces insufficient testosterone.
How Natesto Works
Unlike other testosterone therapies delivered via injections or skin gels, Natesto is applied inside the nose using a metered-dose pump. This intranasal route allows the hormone to be absorbed through the nasal mucosa into the bloodstream.
Key Benefits of Natesto
- Non-invasive and needle-free application
- Reduced risk of testosterone transfer to others (compared to topical gels)
- Convenient dosing three times per day
Dosage and Administration
The typical starting dose is 11 mg of testosterone (5.5 mg per nostril) administered three times daily. Patients should follow their doctor’s instructions carefully and avoid blowing their nose immediately after application.
Common Side Effects
- Nasal irritation or congestion
- Increased blood pressure
- Headache or mood swings
- Changes in red blood cell count
“Natesto is not recommended for use in men with prostate or breast cancer.” — This warning appears in official prescribing information and should be taken seriously.
Who Should Not Use Natesto?
Natesto is not indicated for men with normal testosterone levels or for use in women and children. It should be avoided in individuals with certain cancers, untreated sleep apnea, or serious heart conditions without proper medical evaluation.
Important Considerations
Before starting Natesto, patients should undergo blood tests to confirm low testosterone levels. Regular monitoring during treatment is recommended to assess hormone levels, red blood cell count, and potential side effects.
Sources / Scientific References
- FDA. (2023). Natesto Prescribing Information
- Endo Pharmaceuticals. Official Natesto Website
- Journal of Clinical Endocrinology & Metabolism. (2022). Intranasal Testosterone Therapy in Hypogonadal Men. DOI: 10.1210/clinem/dgac183
- Mayo Clinic. Testosterone Nasal Gel – Drug Information
Note: The phrase “Natesto is not recommended for use in men with prostate or breast cancer” is directly from the FDA prescribing label and is marked as cited content.