Letrozole: Uses, Dosage, Side Effects & Safety Information
Letrozole is a prescription medicine that belongs to a group of drugs called aromatase inhibitors. It is mainly used in the treatment of hormone-dependent breast cancer and is also widely prescribed for ovulation induction in women with infertility, especially those with polycystic ovary syndrome (PCOS).
How Letrozole Works
Letrozole works by blocking the enzyme aromatase, which is responsible for converting androgens into estrogen in the body. By reducing estrogen levels, the medicine helps slow or stop the growth of estrogen-dependent breast cancer cells.
In fertility treatment, lower estrogen levels stimulate the pituitary gland to release more follicle-stimulating hormone (FSH), which helps in the development and release of eggs from the ovary.
Uses of Letrozole
- Treatment of hormone-receptor-positive breast cancer in postmenopausal women
- Prevention of breast cancer recurrence
- Ovulation induction in women with infertility
- Treatment of infertility associated with PCOS
Dosage and Administration
The dosage of Letrozole depends on the medical condition and treatment goal:
- Breast cancer: Usually 2.5 mg once daily
- Ovulation induction: Commonly 2.5–5 mg daily for 5 days (as prescribed by a doctor)
Letrozole tablets are taken orally, with or without food. Always follow the doctor’s instructions and do not self-medicate.
Possible Side Effects
Like all medicines, Letrozole may cause side effects, although not everyone experiences them.
Common Side Effects
- Hot flashes
- Headache
- Fatigue
- Dizziness
- Joint or muscle pain
Less Common but Serious Side Effects
- Bone thinning (osteoporosis)
- High cholesterol levels
- Severe allergic reactions
- Persistent chest pain or shortness of breath
Seek immediate medical attention if severe or unusual symptoms occur.
Precautions and Warnings
- Not recommended during pregnancy or breastfeeding
- Bone density monitoring may be required during long-term use
- Use with caution in patients with liver disease
- Regular medical follow-up is essential
Drug Interactions
Letrozole may interact with certain medications, including hormone replacement therapies and estrogen-containing drugs. Inform your healthcare provider about all medicines and supplements you are taking.
Frequently Asked Questions (FAQs)
Is Letrozole safe for infertility treatment?
Yes, Letrozole is widely used and considered effective for ovulation induction when prescribed and monitored by a fertility specialist.
Can Letrozole cause weight gain?
Weight gain is not common, but some patients may experience fluid retention or changes in metabolism.
How long does Letrozole stay in the body?
Letrozole has a half-life of approximately 2 days, meaning it gradually leaves the body over several days after stopping the medicine.
Conclusion
Letrozole is a clinically proven medicine used in both cancer treatment and fertility management. When used under medical supervision, it offers significant benefits with manageable side effects. Always consult a healthcare professional before starting or stopping Letrozole therapy.
Scientific References
- U.S. Food and Drug Administration (FDA). Letrozole Prescribing Information.
- National Cancer Institute. Hormone Therapy for Breast Cancer.
- American Society for Reproductive Medicine (ASRM). Ovulation Induction Guidelines.
- European Medicines Agency (EMA). Letrozole Assessment Report.
- UpToDate. Aromatase Inhibitors: Pharmacology and Clinical Use.