Overview
Crinone is a vaginal gel that contains progesterone, a naturally occurring female hormone essential for regulating ovulation and maintaining pregnancy. It is commonly prescribed during assisted reproductive technology (ART) treatments, such as IVF, to support the luteal phase and early stages of pregnancy.
Key Ingredients
- Active Ingredient: Progesterone (micronized)
- Form: Vaginal gel
- Concentration: Typically available in 8% formulation
How Crinone Works
Crinone delivers progesterone directly into the vaginal tissue, allowing for localized absorption into the uterus. This hormone prepares the endometrial lining to support the implantation of an embryo and maintain early pregnancy. It is especially beneficial for women who are unable to produce enough progesterone naturally.
Medical Uses
- Luteal phase support in women undergoing IVF or IUI
- Treatment for secondary amenorrhea (absence of menstruation)
- Hormone replacement therapy (HRT) in menopausal women, when combined with estrogen
- Supporting early pregnancy in women with a history of miscarriage related to low progesterone
Benefits of Crinone
- Localized delivery minimizes systemic side effects
- Easy-to-use single-dose applicators
- Long-lasting effect due to bioadhesive gel formulation
- Non-invasive compared to injectable progesterone
Dosage & Administration
- Typically applied once daily (may vary based on prescription)
- Inserted directly into the vagina using a pre-filled applicator
- Treatment usually starts after ovulation or egg retrieval and continues up to 10-12 weeks of pregnancy, if conception occurs
Possible Side Effects
Some women may experience mild side effects, such as:
- Vaginal irritation or discharge
- Breast tenderness
- Cramps or bloating
- Mood swings
- Headache
Seek medical attention if you notice signs of allergic reaction, unusual vaginal bleeding, or severe pain.
Precautions & Warnings
- Not recommended for use in women with a history of breast cancer, liver disease, or blood clots
- Should not be used during pregnancy unless prescribed
- Avoid use with other vaginal products (e.g., douches or antifungals) unless advised by a doctor
- Inform your doctor if you are breastfeeding
Storage
- Store Crinone at room temperature, away from heat and moisture
- Do not refrigerate or freeze
- Keep out of reach of children
Important Notes
- Crinone should be used only under the guidance of a fertility specialist or gynecologist.
- Consistent use as prescribed is crucial for effective treatment.
- Do not skip doses during IVF cycles or early pregnancy support.
Conclusion
Crinone (Progesterone Gel) is a critical medication for many women undergoing fertility treatments. It provides reliable hormone support for the uterine environment and improves the chances of a successful pregnancy. As with all hormonal therapies, follow your doctor’s instructions closely and report any side effects.
Sources / Scientific References
- FDA Drug Label for Crinone
https://www.accessdata.fda.gov - Practice Committee of the American Society for Reproductive Medicine. (2015).
Progesterone supplementation during the luteal phase and in early pregnancy in the treatment of infertility: a committee opinion. Fertility and Sterility, 103(4), e85-e89.
https://doi.org/10.1016/j.fertnstert.2014.12.007 - Kirk, E. et al. (2009).
The use of vaginal progesterone in pregnancy. Obstetrics, Gynaecology & Reproductive Medicine, 19(8), 239-243.
https://doi.org/10.1016/j.ogrm.2009.06.005 - Crinone Prescribing Information (Serono Laboratories)
https://www.drugs.com/pro/crinone.html