What is Vagifem?

Vagifem is a prescription medication that contains a low dose of estradiol, a type of estrogen. It comes in the form of a small tablet that is inserted directly into the vagina. Vagifem is used to relieve symptoms of vaginal atrophy caused by menopause, such as dryness, itching, burning, and painful intercourse.

How Does It Work?

During menopause, estrogen levels drop, which can cause the vaginal lining to thin and dry out. Vagifem delivers estrogen directly to the vaginal tissue, helping to restore moisture, elasticity, and comfort. Because it’s applied locally, systemic absorption is minimal.

Common Uses

• Vaginal dryness and discomfort
• Itching or burning sensation in the vaginal area
• Pain during intercourse (dyspareunia)
• Vaginal inflammation due to low estrogen (atrophic vaginitis)

How to Use Vagifem

Vagifem tablets are inserted into the vagina using a pre-loaded applicator. The usual starting dose is one tablet daily for the first two weeks, followed by a maintenance dose of two tablets per week (e.g., Monday and Thursday). Always follow your doctor’s instructions.

Benefits of Vagifem

• Targets symptoms locally with minimal systemic exposure
• Improves comfort, moisture, and sexual function
• Convenient tablet form with pre-filled applicators

Side Effects

• Vaginal discharge or irritation
• Headache or stomach upset
• Breast tenderness
• Rare: risk of blood clots or stroke (especially with prolonged use)

Consult your doctor if you notice abnormal vaginal bleeding, leg pain, or signs of allergic reaction.

Warnings and Precautions

• Do not use if pregnant or breastfeeding
• Avoid if you have a history of estrogen-dependent cancers
• Regular check-ups are recommended during long-term use

Frequently Asked Questions

Is Vagifem safe for long-term use?

It may be used long-term under medical supervision. The lowest effective dose should be used for the shortest time needed.

Can I use Vagifem with other hormone therapies?

Only under a doctor’s guidance. Combining multiple estrogen therapies may increase risks.

When will I start seeing results?

Most women notice improvements within a few weeks of starting treatment.