Anastrozole: Uses, Dosage, Side Effects & Safety Information
Anastrozole is a prescription medicine belonging to the class of aromatase inhibitors. It is mainly prescribed for the treatment of hormone receptor-positive breast cancer in postmenopausal women. The medicine helps reduce estrogen levels in the body, which slows the growth of estrogen-dependent cancer cells.
Mechanism of Action
Anastrozole works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens into estrogen. Lower estrogen levels help prevent the progression and recurrence of hormone-sensitive breast cancer.
Uses of Anastrozole
- Treatment of early hormone receptor-positive breast cancer
- Advanced or metastatic breast cancer
- Prevention of breast cancer recurrence
- Alternative to tamoxifen in postmenopausal women
Dosage and Administration
The typical recommended dose of Anastrozole is:
- 1 mg once daily, taken orally
The tablet may be taken with or without food. Treatment duration depends on the clinical condition and should be followed exactly as prescribed by a healthcare professional.
Possible Side Effects
Common Side Effects
- Hot flashes
- Joint pain or stiffness
- Weakness or fatigue
- Headache
- Nausea
Less Common but Serious Side Effects
- Bone loss (osteoporosis)
- Increased risk of fractures
- High cholesterol levels
- Allergic reactions
Precautions and Warnings
- Not recommended for premenopausal women
- Contraindicated during pregnancy and breastfeeding
- Bone density monitoring is advised during long-term therapy
- Use cautiously in patients with liver impairment
Drug Interactions
Anastrozole should not be used with estrogen-containing medications, including hormone replacement therapy. Inform your doctor about all medicines, supplements, or herbal products you are taking.
Frequently Asked Questions (FAQs)
Is Anastrozole better than tamoxifen?
In many postmenopausal women, Anastrozole may be more effective than tamoxifen in reducing the risk of breast cancer recurrence, depending on individual medical factors.
Can Anastrozole cause bone pain?
Yes, joint and bone pain are commonly reported side effects due to reduced estrogen levels.
Conclusion
Anastrozole is an effective hormone therapy for estrogen-dependent breast cancer in postmenopausal women. With proper medical supervision, its benefits often outweigh potential risks. Regular monitoring helps ensure safe and effective treatment.
Scientific References
- U.S. Food and Drug Administration (FDA). Anastrozole Prescribing Information.
- National Cancer Institute. Hormone Therapy for Breast Cancer.
- European Medicines Agency (EMA). Anastrozole Assessment Report.
- American Cancer Society. Breast Cancer Hormone Therapy.
- UpToDate. Aromatase Inhibitors in Breast Cancer Treatment.